Incretin hormones and the satiation signal
نویسندگان
چکیده
منابع مشابه
Incretin hormones as immunomodulators of atherosclerosis
Atherosclerosis results from endothelial cell dysfunction and inflammatory processes affecting both macro- and microvasculature which are involved in vascular diabetic complications. Glucagon-like peptide-1 (GLP-1) is an incretin hormone responsible for amplification of insulin secretion when nutrients are given orally as opposed to intravenously and it retains its insulinotropic activity in pa...
متن کاملBone: Incretin Hormones Perceiver or Receiver?
Novel incretin-based drugs, such as glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase-4 inhibitors (DPP-4i), have been last introduced in the pharmacological treatment of type 2 diabetes. In the last few years, the interest on the relationship of gut hormones with bone metabolism in diabetes has been increasing. The aim of present paper is to examine in vitro and in ...
متن کاملGIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice.
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are gut-derived incretins secreted in response to nutrient ingestion. Both incretins potentiate glucose-dependent insulin secretion and enhance beta-cell mass through regulation of beta-cell proliferation, neogenesis and apoptosis. In contrast, GLP-1, but not GIP, inhibits gastric emptying, glucagon secretion...
متن کاملGut-derived incretin hormones and new therapeutic approaches.
Physiology of glucagon-like peptide 1 action Alan Cherrington (Nashville, TN) described a series of studies of peripheral and hepatic arterial and portal vein flow measurement and sampling that allowed for the assessment of hepatic glucose balance and effects of glucagon-like peptide (GLP)-1. In a study comparing peripheral with portal venous glucose delivery during hyperglycemia (glucose incre...
متن کاملEnhancing the action of incretin hormones: a new whey forward?
The gastrointestinal tract is an often overlooked but complex endocrine organ, home to dozens of regulatory peptides produced in specialized endocrine cells and enteric neurons. These hormones subserve complex roles as signals regulating appetite, gastrointestinal motility, control of secretion from the exocrine and endocrine pancreas, and nutrient absorption (1). The majority of gut peptides a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 2013
ISSN: 0307-0565,1476-5497
DOI: 10.1038/ijo.2012.208